The phage-host arms race: shaping the evolution of microbes.

  title={The phage-host arms race: shaping the evolution of microbes.},
  author={Adi Stern and Rotem Sorek},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={33 1},
Bacteria, the most abundant organisms on the planet, are outnumbered by a factor of 10 to 1 by phages that infect them. Faced with the rapid evolution and turnover of phage particles, bacteria have evolved various mechanisms to evade phage infection and killing, leading to an evolutionary arms race. The extensive co-evolution of both phage and host has resulted in considerable diversity on the part of both bacterial and phage defensive and offensive strategies. Here, we discuss the unique and… CONTINUE READING