The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.

@article{Price1999ThePG,
  title={The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.},
  author={Ric N Price and Claire Cassar and Alan Brockman and Manoj Duraisingh and Mich{\`e}le van Vugt and Nicholas J White and François H Nosten and Sanjeev Krishna},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 12},
  pages={2943-9}
}
On the western border of Thailand, Plasmodium falciparum has become resistant to almost all antimalarial agents. The molecular basis of resistance in these parasite populations has not been well characterized. This study assessed genetic polymorphisms in the pfmdr1 gene in 54 parasites collected from the western border of Thailand to determine the relationship of pfmdr1 copy number and codon mutations with parasite sensitivities to mefloquine, chloroquine, halofantrine, quinine, and artesunate… CONTINUE READING

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Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria.

Transactions of the Royal Society of Tropical Medicine and Hygiene • 1997

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