The pervasiveness and plasticity of circadian oscillations: the coupled circadian-oscillators framework

@article{Patel2015ThePA,
  title={The pervasiveness and plasticity of circadian oscillations: the coupled circadian-oscillators framework},
  author={Vishal R. Patel and Nicholas Ceglia and Michael Zeller and Kristin Eckel-Mahan and Paolo Sassone-Corsi and Pierre Baldi},
  journal={Bioinformatics},
  year={2015},
  volume={31 19},
  pages={3181-8}
}
MOTIVATION Circadian oscillations have been observed in animals, plants, fungi and cyanobacteria and play a fundamental role in coordinating the homeostasis and behavior of biological systems. Genetically encoded molecular clocks found in nearly every cell, based on negative transcription/translation feedback loops and involving only a dozen genes, play a central role in maintaining these oscillations. However, high-throughput gene expression experiments reveal that in a typical tissue, a much… CONTINUE READING
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