The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells.

@article{Schrader1981TheP,
  title={The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells.},
  author={John W Schrader and Samuel J Lewis and I Clark-lewis and Janetta Gladys Culvenor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 1},
  pages={323-7}
}
Histamine was detected at levels of 100 ng/10(6) cells in the metachromatic granules of the persisting (P) cell, which appears in cultures of murine lymphoid or bone marrow cells and is capable of long-term growth in vitro in the presence of a T cell-derived growth factor. This factor, which we termed P-cell stimulating factor, was distinct from t-cell growth factor and had an apparent molecular weight of 25,000-30,000. P cells did not originate from Thy.1-positive cells nor was the thymus… CONTINUE READING