The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis

@article{Frisullo2008ThePO,
  title={The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis},
  author={Giovanni Frisullo and Viviana Nociti and Raffaele Iorio and Agata Katia Patanella and Alessandro Marti and Massimiliano Mirabella and Pietro Attilio Tonali and Anna Paola Batocchi},
  journal={Journal of Neuroimmunology},
  year={2008},
  volume={205},
  pages={126-134}
}
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22 Citations
Background Citations
9
Methods Citations
1

22 Citations

pSTAT1, pSTAT3, and T‐bet as markers of disease activity in chronic inflammatory demyelinating polyradiculoneuropathy
TLDR
The data suggest that pSTAT1, T‐bet, and pSTAT3 can be considered putative markers of disease activity and potential targets for specific therapies.
Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis.
TLDR
A number of significant changes in both the CD4+ and CD8+ T-cells subsets from MS post-transplant are confirmed and extended with quantitative data, including more extensive changes in the expression of genes involved in effector immune responses.
Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients
TLDR
The findings suggest that the aberrant activation of this pathway could lead to changes in the expression of HLA molecules in antigen presenting cells, which are known to play important roles in the regulation of the immune response in health and disease.
Progesterone Dampens Immune Responses in In Vitro Activated CD4+ T Cells and Affects Genes Associated With Autoimmune Diseases That Improve During Pregnancy
TLDR
The previous knowledge of P4 as an immune regulatory hormone is extended and its importance during pregnancy for regulating potentially detrimental immune responses towards the semi-allogenic fetus is supported.
Progesterone specifically dampens disease-associated TH1- and TH17-related immune responses during T cell activation in vitro
TLDR
P4 had a profound dampening effect on T cell activation, altering the gene and protein expression profile and opposing many of the changes induced during the activation, which supports its importance during pregnancy for regulating potentially detrimental immune responses towards the semi-allogenic fetus.
The regulation of reactive changes around multiple sclerosis lesions by phosphorylated signal transducer and activator of transcription.
TLDR
The findings show that pSTAT3 does not correlate with inflammatory activity in MS lesions, but that it may play an important role in regulating reactive changes proximal to MS lesions.
Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases.
TLDR
Recent advancements in the understanding of the involvement of the JAK/STAT signaling pathway in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis are discussed, with a particular focus on therapeutic approaches to target the Jak/STAT pathway.
Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10.
STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility
TLDR
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population, and a major role of this gene in MS seems unlikely.
Experimental Autoimmune JAK/STAT Pathway in Multiple Models of Therapeutic Efficacy of Suppressing the
TLDR
Inhibition of the JAK/STAT pathway has clinical efficacy in multiple preclinical models of MS, suggesting the feasibility of theJAK/ STAT pathway as a target for neuroinflammatory diseases.
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References

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TLDR
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TLDR
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