The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis

@article{Frisullo2008ThePO,
  title={The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis},
  author={Giovanni Frisullo and Viviana Nociti and Raffaele Iorio and Agata Katia Patanella and Alessandro Marti and Massimiliano Mirabella and Pietro Attilio Tonali and Anna Paola Batocchi},
  journal={Journal of Neuroimmunology},
  year={2008},
  volume={205},
  pages={126-134}
}
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TLDR
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TLDR
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Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases.
TLDR
Recent advancements in the understanding of the involvement of the JAK/STAT signaling pathway in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis are discussed, with a particular focus on therapeutic approaches to target the Jak/STAT pathway.
STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility
TLDR
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population, and a major role of this gene in MS seems unlikely.
Experimental Autoimmune JAK/STAT Pathway in Multiple Models of Therapeutic Efficacy of Suppressing the
TLDR
Inhibition of the JAK/STAT pathway has clinical efficacy in multiple preclinical models of MS, suggesting the feasibility of theJAK/ STAT pathway as a target for neuroinflammatory diseases.
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