The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism.

  title={The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism.},
  author={Michael Stumvoll and H. U. H{\"a}ring},
  volume={51 8},
Peroxisome proliferator-activated receptor (PPAR)-gamma is a transcription factor with a key role in adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-gamma2 is associated with reduced risk for type 2 diabetes. The effect on the individual is weak, but because of a prevalence of >75% of the high-risk Pro allele, the population-attributable risk is enormous. The in vivo effects of the polymorphism are secondary to alterations in adipose tissue… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…