The peroxisomal protein import machinery displays a preference for monomeric substrates

@article{Freitas2015ThePP,
  title={The peroxisomal protein import machinery displays a preference for monomeric substrates},
  author={M. O. Freitas and T. Francisco and T. Rodrigues and Celien Lismont and P. Domingues and M. P. Pinto and C. Grou and M. Fransen and Jorge E Azevedo},
  journal={Open Biology},
  year={2015},
  volume={5}
}
Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported by the shuttling receptor PEX5 to the peroxisomal membrane docking/translocation machinery, where they are translocated into the organelle matrix. Under certain experimental conditions this protein import machinery has the remarkable capacity to accept already oligomerized proteins, a property that has heavily influenced current models on the mechanism of peroxisomal protein import. However, whether or not… Expand
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