The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress.

@article{Walton2017ThePI,
  title={The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress.},
  author={P. Walton and C. Brees and Celien Lismont and O. Apanasets and M. Fransen},
  journal={Biochimica et biophysica acta. Molecular cell research},
  year={2017},
  volume={1864 10},
  pages={
          1833-1843
        }
}
Accumulating evidence indicates that peroxisome functioning, catalase localization, and cellular oxidative balance are intimately interconnected. Nevertheless, it remains largely unclear why modest increases in the cellular redox state especially interfere with the subcellular localization of catalase, the most abundant peroxisomal antioxidant enzyme. This study aimed at gaining more insight into this phenomenon. Therefore, we first established a simple and powerful approach to study… Expand
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