The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives.

  title={The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives.},
  author={Gennaro Agrimi and Annamaria Russo and Ciro Leonardo Pierri and Ferdinando Palmieri},
  journal={Journal of bioenergetics and biomembranes},
  volume={44 3},
The peroxisomal protein PXN encoded by the Arabidopsis gene At2g39970 has very recently been found to transport NAD+, NADH, AMP and ADP. In this work we have reinvestigated the substrate specificity and the transport properties of PXN by using a wide range of potential substrates. Heterologous expression in bacteria followed by purification, reconstitution in liposomes, and uptake and efflux experiments revealed that PNX transports coenzyme A (CoA), dephospho-CoA, acetyl-CoA and adenosine 3', 5… CONTINUE READING


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