The permissive role of endothelial NO in CO-induced cerebrovascular dilation.

  title={The permissive role of endothelial NO in CO-induced cerebrovascular dilation.},
  author={E. Barkoudah and J. H. Jaggar and C. Leffler},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={287 4},
  • E. Barkoudah, J. H. Jaggar, C. Leffler
  • Published 2004
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • Carbon monoxide (CO) and nitric oxide (NO) are important paracrine messengers in the newborn cerebrovasculature that may act as comessengers. Here, we investigated the role of NO in CO-mediated dilations in the newborn cerebrovasculature. Arteriolar branches of the middle cerebral artery (100-200 microm) were isolated from 3- to 7-day-old piglets and cannulated at each end in a superfusion chamber, and intravascular pressure was elevated to 30 mmHg, which resulted in the development of myogenic… CONTINUE READING
    52 Citations
    Time-dependent action of carbon monoxide on the newborn cerebrovascular circulation.
    • 20
    • PDF
    Permissive contributions of NO and prostacyclin in CO-induced cerebrovascular dilation in piglets.
    • 28
    • PDF
    Mechanisms of the vasorelaxing effects of CORM-3, a water-soluble carbon monoxide-releasing molecule: interactions with eNOS
    • 15
    Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice.
    • 38
    Carbon Monoxide-Mediated Activation of Large-Conductance Calcium-Activated Potassium Channels Contributes to Mesenteric Vasodilatation in Cirrhotic Rats
    • 61
    • Highly Influenced
    • PDF
    • 14
    Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers.
    • Xinyue Qin, H. Kwansa, +4 authors R. Koehler
    • Medicine, Chemistry
    • American journal of physiology. Regulatory, integrative and comparative physiology
    • 2008
    • 9
    • PDF
    Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury.
    • 38
    • PDF


    Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets.
    • 48
    • PDF
    Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets.
    • 51
    • PDF
    Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine.
    • 116
    Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.
    • 68
    • PDF
    Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors.
    • 181
    • PDF
    Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS.
    • 224
    Carbon monoxide and cerebral microvascular tone in newborn pigs.
    • 155
    • PDF
    Role of nitric oxide and cAMP in prostaglandin-induced pial arterial vasodilation.
    • W. Armstead
    • Biology, Medicine
    • The American journal of physiology
    • 1995
    • 53