The permissive role of endothelial NO in CO-induced cerebrovascular dilation.

@article{Barkoudah2004ThePR,
  title={The permissive role of endothelial NO in CO-induced cerebrovascular dilation.},
  author={E. Barkoudah and J. H. Jaggar and C. Leffler},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 4},
  pages={
          H1459-65
        }
}
  • E. Barkoudah, J. H. Jaggar, C. Leffler
  • Published 2004
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • Carbon monoxide (CO) and nitric oxide (NO) are important paracrine messengers in the newborn cerebrovasculature that may act as comessengers. Here, we investigated the role of NO in CO-mediated dilations in the newborn cerebrovasculature. Arteriolar branches of the middle cerebral artery (100-200 microm) were isolated from 3- to 7-day-old piglets and cannulated at each end in a superfusion chamber, and intravascular pressure was elevated to 30 mmHg, which resulted in the development of myogenic… CONTINUE READING
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