The permeability transition pore complex: another view.

  title={The permeability transition pore complex: another view.},
  author={Andrew Philip Halestrap and Gavin P. McStay and Samantha J. Clarke},
  volume={84 2-3},
Mitochondria play a critical role in initiating both apoptotic and necrotic cell death. A major player in this process is the mitochondrial permeability transition pore (MPTP), a non-specific pore, permeant to any molecule of < 1.5 kDa, that opens in the inner mitochondrial membrane under conditions of elevated matrix [Ca(2+)], especially when this is accompanied by oxidative stress and depleted adenine nucleotides. Opening of the MPTP causes massive swelling of mitochondria, rupture of the… CONTINUE READING
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