The permeability of the endoplasmic reticulum is dynamically coupled to protein synthesis.

  title={The permeability of the endoplasmic reticulum is dynamically coupled to protein synthesis.},
  author={Anirban Roy and William F. Wonderlin},
  journal={The Journal of biological chemistry},
  volume={278 7},
Proteins synthesized by the rough endoplasmic reticulum (RER) co-translationally cross the membrane through the pore of a ribosome-bound translocon (RBT) complex. Although this pore is also permeable to small molecules, it is generally thought that barriers to their permeation prevent the cyclical process of protein translation from affecting the permeability of the RER. We tested this hypothesis by culturing Chinese hamster ovary-S cells with inhibitors of protein translation that affect the… CONTINUE READING
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