The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics.

@article{Notman2007ThePE,
  title={The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics.},
  author={Rebecca Notman and Wouter K den Otter and Massimo G. Noro and W. J. Briels and Jamshed Anwar},
  journal={Biophysical journal},
  year={2007},
  volume={93 6},
  pages={2056-68}
}
The lipids of the topmost layer of the skin, the stratum corneum, represent the primary barrier to molecules penetrating the skin. One approach to overcoming this barrier for the purpose of delivery of active molecules into or via the skin is to employ chemical permeability enhancers, such as dimethylsulfoxide (DMSO). How these molecules exert their effect at the molecular level is not understood. We have investigated the interaction of DMSO with gel-phase bilayers of ceramide 2, the… CONTINUE READING
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