The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma.

@article{Mori2007ThePS,
  title={The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma.},
  author={Kazuya Mori and Manami Itoi and Noriyuki Tsukamoto and Hajime Kubo and Takashi Amagai},
  journal={International immunology},
  year={2007},
  volume={19 6},
  pages={
          745-53
        }
}
It is known that selected populations of lymphoid cells migrate into and from the adult thymus through blood vessels at the cortico-medullary junction and in the medulla. Here, we show that in the perivascular spaces (PVS) of mice surrounding large blood vessels, CD117-positive hematopoietic progenitor cells, CD4 single-positive (SP) and CD8SP T cells are located. However, developing thymocytes, CD25-positive cells and CD4 and CD8 double-positive cells, are not detectable in the PVS. After… CONTINUE READING

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