The perivascular niche regulates breast tumor dormancy

@article{Ghajar2013ThePN,
  title={The perivascular niche regulates breast tumor dormancy},
  author={Cyrus M. Ghajar and H{\'e}ctor Peinado and Hidetoshi Mori and Irina Matei and Kimberley J. Evason and H{\'e}l{\`e}ne Brazier and Dena Almeida and Antonius A. Koller and Katherine A. Hajjar and Didier Y. R. Stainier and Emily I. Chen and David C. Lyden and Mina J. Bissell},
  journal={Nature cell biology},
  year={2013},
  volume={15},
  pages={807 - 817}
}
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what wakes them up, are fundamental problems in tumour biology. To address these questions, we used metastasis assays in mice and showed that dormant DTCs reside on microvasculature of lung, bone marrow and brain. We then engineered organotypic microvascular niches to determine whether endothelial cells directly… 
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