The perivascular niche regulates breast tumor dormancy

@article{Ghajar2013ThePN,
  title={The perivascular niche regulates breast tumor dormancy},
  author={Cyrus M. Ghajar and H{\'e}ctor Peinado and Hidetoshi Mori and Irina Matei and Kimberley J. Evason and H{\'e}l{\`e}ne Brazier and Dena Almeida and Antonius A. Koller and Katherine A. Hajjar and Didier Y. R. Stainier and Emily I. Chen and David C. Lyden and Mina J. Bissell},
  journal={Nature cell biology},
  year={2013},
  volume={15},
  pages={807 - 817}
}
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what wakes them up, are fundamental problems in tumour biology. To address these questions, we used metastasis assays in mice and showed that dormant DTCs reside on microvasculature of lung, bone marrow and brain. We then engineered organotypic microvascular niches to determine whether endothelial cells directly… 
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811 Citations

A perivascular niche in the bone marrow hosts quiescent and proliferating tumorigenic colorectal cancer cells
TLDR
An important role of the perivascular BM niche for CRC cell dissemination is indicated and dTCs can be a potential source for tumor relapse and tumor heterogeneity.
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.
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Using serial intravital imaging of dormant and metastatic triple-negative breast cancer lines, escape from the single-cell or micrometastatic state is identified as the rate-limiting step towards brain metastasis.
Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy.
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Prostate Cancer Dormancy and Reactivation in Bone Marrow
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Recent discoveries that have improved the understanding of dormancy signaling and the role of the TME in modulating the epigenetic reprogramming of DCCs are discussed.
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It is demonstrated that ANGPT2 signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 receptor and partly directly via tumor cell surface integrin &1.
Molecular Pathways: Niches in Metastatic Dormancy
TLDR
T tumor dormancy from the perspective of the niche is discussed and potential therapeutic targets are considered to help guide innovation in the care of patients with advanced cancer.
In vitro Models of Breast Cancer Metastatic Dormancy
TLDR
In vitro models designed to study metastatic dormancy of breast cancer cells (BCCs) are focused on and components of the metastatic microenvironment that have been shown to impact on the dormant phenotype are addressed.
Human bone perivascular niche-on-a-chip for studying metastatic colonization
TLDR
It is proposed that the bone perivascular niche-on-a-chip with interstitial flow promotes the formation of stable vasculature and mediates cancer cell colonization and persists in a slow-proliferative state associated with increased drug resistance.
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy
TLDR
Evidence is provided that the microenvironment of DTCs protects them from chemotherapy, independent of cell cycle status, and that prefacing adjuvant therapy with integrin inhibitors is a viable clinical strategy to eradicate D TCs and prevent metastasis.
A possible IDO1- TSP1 role in breast cancer dormancy
TLDR
The data presented here suggests that endothelial cells induce breast cancer dormancy and drug resistance via TSP1, and suggests that an IFNγ/IDO1 pathway might decrease T SP1 synthesis leading to cancer cell proliferation and angiogenesis.
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