The peripherally acting kappa-opiate agonist EMD 61753 and analogues: opioid activity versus peripheral selectivity.


EMD 61753 (N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl) -ethyl ]- 2,2-diphenyl-acetamide hydrochloride) is a peripherally selective kappa-opiate agonist. It exhibits antihyperalgesic activity in animal models of inflammatory pain at doses which do not cause signs of central action. The structure of this compound was varied in different ways… (More)


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