The peripheral antinociceptive effect induced by the heme oxygenase/carbon monoxide pathway is associated with ATP-sensitive K+ channels.

@article{vila2014ThePA,
  title={The peripheral antinociceptive effect induced by the heme oxygenase/carbon monoxide pathway is associated with ATP-sensitive K+ channels.},
  author={Mara Aparecida Pereira de {\'A}vila and Alexandre Giusti-Paiva and Carlos Giovani de Oliveira Nascimento},
  journal={European journal of pharmacology},
  year={2014},
  volume={726},
  pages={
          41-8
        }
}
Carbon monoxide (CO), a product of the enzyme heme oxygenase (HO), has been recognized to act as an atypical neurotransmitter or neuromodulator in the nervous system, and several lines of evidence suggest that CO may play a role through multiple mechanisms in nociceptive processing. Therefore, the aim of our study was to assess the interaction between the HO/CO pathway and ATP-sensitive K+ channels in hypernociception in response to carrageenan. The electronic von Frey and Randall Selitto tests… CONTINUE READING