The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism.

@article{SteegersTheunissen2013ThePP,
  title={The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism.},
  author={R{\'e}gine P M Steegers-Theunissen and John M. Twigt and Valerie Pestinger and Kevin D Sinclair},
  journal={Human reproduction update},
  year={2013},
  volume={19 6},
  pages={
          640-55
        }
}
BACKGROUND Most reproductive failures originate during the periconceptional period and are influenced by the age and the lifestyle of parents-to-be. We advance the hypothesis that these failures can arise as a partial consequence of derangements to one-carbon (1-C) metabolism (i.e. metabolic pathways that utilize substrates/cofactors such as methionine, vitamin B12, folate). 1-C metabolic pathways drive the synthesis of proteins, biogenic amines and lipids required for early growth, together… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 102 CITATIONS, ESTIMATED 56% COVERAGE

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 16 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 184 REFERENCES

Hormonal regulation of cystathionine beta-synthase expression in liver.

  • The Journal of biological chemistry
  • 2002
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Maternal inheritance of cardiovascular disease in families and congenital heart disease in offspring

KPJ Wijnands, SA Obermann-Borst, +3 authors RPM. Steegers-Theunissen
  • Reprod Sci 2012;10:345A
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL