The perfused everted intestinal segment of rat. 1st communication: absorption kinetics of markers of different permeation mechanisms.

@article{Gandia2004ThePE,
  title={The perfused everted intestinal segment of rat. 1st communication: absorption kinetics of markers of different permeation mechanisms.},
  author={Peggy Gandia and Olivier Lacombe and John M. Woodley and Georges Houin},
  journal={Arzneimittel-Forschung},
  year={2004},
  volume={54 8},
  pages={
          467-73
        }
}
The optimisation of the intestinal absorption of drugs represents one of the most important steps in the development of new pharmacologically active products. Several in vitro models are commonly used to study the mechanisms involved in drug absorption and all have advantages and disadvantages, notably they are often very static, and rarely take into account the intestinal motility and blood flow. The aim of this project was to validate a new ex vivo/in vitro model to study drug absorption, the… CONTINUE READING