The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.

@article{Ghosh2013ThePI,
  title={The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.},
  author={Anamitra Ghosh and Hariharan Saminathan and Arthi Kanthasamy and Vellareddy Anantharam and Huajun Jin and Gautam V. Sondarva and Dilshan S Harischandra and Ziqing Qian and A. S. Rana and Anumantha G Kanthasamy},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 30},
  pages={21955-71}
}
Parkinson disease (PD) is a chronic neurodegenerative disease characterized by a slow and progressive degeneration of dopaminergic neurons in substantia nigra. The pathophysiological mechanisms underlying PD remain unclear. Pin1, a major peptidyl-prolyl isomerase, has recently been associated with certain diseases. Notably, Ryo et al. (Ryo, A., Togo, T… CONTINUE READING