The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis

@inproceedings{Medvedeva2013ThePS,
  title={The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis},
  author={Ekaterina V. Medvedeva and Veronika G. Dmitrieva and Oksana V. Povarova and Svetlana A Limborska and Veronika I. Skvortsova and Nikolay F. Myasoedov and Lyudmila V Dergunova},
  booktitle={BMC Genomics},
  year={2013}
}
BackgroundThe nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke; however, the molecular mechanisms underlying its action remain obscure. Our genome-wide study was designed to investigate the response of the transcriptome of ischemized rat brain cortex tissues to the action of Semax in vivo.ResultsThe gene-expression alteration caused by the action of the peptide Semax was compared with the gene expression of the “ischemia… CONTINUE READING

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