The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule.

@article{Vartdal1996ThePB,
  title={The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule.},
  author={Frode Vartdal and Baard H. Rehn Johansen and Thomas Friede and Christopher J. Thorpe and Stefan Stevanovi{\'c} and Judit Eriksen and Knut Sletten and Erik Thorsby and Hans Georg Rammensee and Ludvig M. Sollid},
  journal={European journal of immunology},
  year={1996},
  volume={26 11},
  pages={2764-72}
}
To identify the binding motifs of peptides which bind to the celiac disease and insulin-dependent-diabetes-mellitus (IDDM)-associated DQ2 molecule, peptides were eluted from affinity-purified DQ2 molecules. The eluted peptides were separated by reverse-phase HPLC. Prominent peptide peaks and the remaining pool of peptides were sequenced by Edman degradation. Truncated variants of eight different peptides with a length of 9-19 amino acids were identified; among them class II-associated invariant… CONTINUE READING

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