The peptide VIP is a neurotransmitter in rat adrenal medulla: physiological role in controlling catecholamine secretion.

@article{Wakade1991ThePV,
  title={The peptide VIP is a neurotransmitter in rat adrenal medulla: physiological role in controlling catecholamine secretion.},
  author={Taruna D. Wakade and Marion A. Blank and Ravindra K. Malhotra and Roberta G Pourcho and Arun R. Wakade},
  journal={The Journal of physiology},
  year={1991},
  volume={444},
  pages={349-62}
}
1. The perfused adrenal gland of the rat was used to establish the identity of a non-cholinergic substance involved in splanchnic nerve-mediated secretion of catecholamines. 2. The perfused adrenal medulla was rich in vasoactive intestinal polypeptide (VIP) content (28 pmol g-1 of wet tissue). VIP-immunoreactive nerve fibres were present in the adrenal medulla and the adrenal cortex. 3. Field stimulation (10 Hz for 15 min plus 1 Hz for 15 min) caused a large increase in the output of VIP in the… CONTINUE READING