The peptidases of Trypanosoma cruzi: digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death.

@article{Alvarez2012ThePO,
  title={The peptidases of Trypanosoma cruzi: digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death.},
  author={Vanina Eder Alvarez and Gabriela T Niemirowicz and Juan Jos{\'e} Cazzulo},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1824 1},
  pages={195-206}
}
Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among these enzymes is cruzipain, a cysteine proteinase expressed as a mixture of isoforms, some of them membrane-bound. The enzyme is an immunodominant antigen in human chronic Chagas disease and seems to be important in the host/parasite relationship. Inhibitors of cruzipain kill the parasite and cure infected mice, thus… CONTINUE READING