The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate.

@article{Riganti2012ThePP,
  title={The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate.},
  author={Chiara Riganti and Elena Gazzano and Manuela Polimeni and Elisabetta Aldieri and Dario Ghigo},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 3},
  pages={
          421-36
        }
}
The pentose phosphate pathway, one of the main antioxidant cellular defense systems, has been related for a long time almost exclusively to its role as a provider of reducing power and ribose phosphate to the cell. In addition to this "traditional" correlation, in the past years multiple roles have emerged for this metabolic cascade, involving the cell cycle, apoptosis, differentiation, motility, angiogenesis, and the response to anti-tumor therapy. These findings make the pentose phosphate… CONTINUE READING
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