The pentanucleotide ATTGG, the "inverted CCAAT," is an essential element for HLA class I gene transcription.

@article{Schoneich1997ThePA,
  title={The pentanucleotide ATTGG, the "inverted CCAAT," is an essential element for HLA class I gene transcription.},
  author={J Schoneich and J. L. Lee and Patrick Mansky and M Sheffery and Soo Young Yang},
  journal={Journal of immunology},
  year={1997},
  volume={158 10},
  pages={4788-96}
}
The HLA class I genes, HLA-A, -B, and -C, contain an inverted CCAAT sequence (ATTGG) located 20 bp upstream of the canonical CCAAT and approximately 70 bp upstream of the transcription initiation site. We have investigated the transcriptional function of the class I inverted CCAAT sequence using the HLA-normal cell line, HeLa. Deletion, mutation, or inversion of the inverted CCAAT sequence abrogated or reduced the activity of the class I promoter, as assessed by luciferase reporter gene assays… CONTINUE READING

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