The pentagastrin test in the diagnosis of the carcinoid syndrome. Blockade of gastrointestinal symptoms by ketanserin.

@article{Ahlman1985ThePT,
  title={The pentagastrin test in the diagnosis of the carcinoid syndrome. Blockade of gastrointestinal symptoms by ketanserin.},
  author={Hakan BJ Ahlman and Annica Dahlstr{\"o}m and K. O. Gr{\"o}nstad and L. E. Tisell and Kjell E Oberg and M. J. Zinner and Bernard M. Jaffe},
  journal={Annals of surgery},
  year={1985},
  volume={201 1},
  pages={81-6}
}
The levels of 5-hydroxytryptamine (serotonin, 5-HT) and substance P (SP) were assayed (using high performance liquid chromatography-electron capture and radioimmunoassay methods) in the peripheral blood of 17 patients with known mid-gut carcinoids, 16 of whom had hepatic metastases. All patients had supranormal basal levels of 5-HT and SP. The clinical and hormonal changes induced by two provocation tests, intravenous pentagastrin (PG) and calcium infusion, were compared. Pentagastrin caused… CONTINUE READING

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The authors conclude that 1 ) 5-HT may be responsible for the gastrointestinal symptoms in carcinoid patients , but it does not seem to play any role in flushing ; 2 ) ketanserin may be a useful therapeutic agent in alleviating gastrointestinal symptoms in carcinoid patients ; 3 ) differential responses to PG suggests that SP is released from a site different from that of 5-HT ; 4 ) it is possible that SP may contribute to the mediation of flushing , but it can not be the sole agent causing this symptom ; and 5 ) the pentagastrin test with measurements of 5-HT levels in peripheral blood seems to be superior to calcium infusion as a provocative test in documenting the diagnosis of carcinoid disease .
Pentagastrin caused flushing in all the patients , induced gastrointestinal symptoms in all but one of the patients with hepatic involvement , and universally elevated circulating 5-HT levels .
The authors conclude that 1 ) 5-HT may be responsible for the gastrointestinal symptoms in carcinoid patients , but it does not seem to play any role in flushing ; 2 ) ketanserin may be a useful therapeutic agent in alleviating gastrointestinal symptoms in carcinoid patients ; 3 ) differential responses to PG suggests that SP is released from a site different from that of 5-HT ; 4 ) it is possible that SP may contribute to the mediation of flushing , but it can not be the sole agent causing this symptom ; and 5 ) the pentagastrin test with measurements of 5-HT levels in peripheral blood seems to be superior to calcium infusion as a provocative test in documenting the diagnosis of carcinoid disease .
The authors conclude that 1 ) 5-HT may be responsible for the gastrointestinal symptoms in carcinoid patients , but it does not seem to play any role in flushing ; 2 ) ketanserin may be a useful therapeutic agent in alleviating gastrointestinal symptoms in carcinoid patients ; 3 ) differential responses to PG suggests that SP is released from a site different from that of 5-HT ; 4 ) it is possible that SP may contribute to the mediation of flushing , but it can not be the sole agent causing this symptom ; and 5 ) the pentagastrin test with measurements of 5-HT levels in peripheral blood seems to be superior to calcium infusion as a provocative test in documenting the diagnosis of carcinoid disease .
The authors conclude that 1 ) 5-HT may be responsible for the gastrointestinal symptoms in carcinoid patients , but it does not seem to play any role in flushing ; 2 ) ketanserin may be a useful therapeutic agent in alleviating gastrointestinal symptoms in carcinoid patients ; 3 ) differential responses to PG suggests that SP is released from a site different from that of 5-HT ; 4 ) it is possible that SP may contribute to the mediation of flushing , but it can not be the sole agent causing this symptom ; and 5 ) the pentagastrin test with measurements of 5-HT levels in peripheral blood seems to be superior to calcium infusion as a provocative test in documenting the diagnosis of carcinoid disease .
Pentagastrin caused flushing in all the patients , induced gastrointestinal symptoms in all but one of the patients with hepatic involvement , and universally elevated circulating 5-HT levels .
The authors conclude that 1 ) 5-HT may be responsible for the gastrointestinal symptoms in carcinoid patients , but it does not seem to play any role in flushing ; 2 ) ketanserin may be a useful therapeutic agent in alleviating gastrointestinal symptoms in carcinoid patients ; 3 ) differential responses to PG suggests that SP is released from a site different from that of 5-HT ; 4 ) it is possible that SP may contribute to the mediation of flushing , but it can not be the sole agent causing this symptom ; and 5 ) the pentagastrin test with measurements of 5-HT levels in peripheral blood seems to be superior to calcium infusion as a provocative test in documenting the diagnosis of carcinoid disease .
The authors conclude that 1 ) 5-HT may be responsible for the gastrointestinal symptoms in carcinoid patients , but it does not seem to play any role in flushing ; 2 ) ketanserin may be a useful therapeutic agent in alleviating gastrointestinal symptoms in carcinoid patients ; 3 ) differential responses to PG suggests that SP is released from a site different from that of 5-HT ; 4 ) it is possible that SP may contribute to the mediation of flushing , but it can not be the sole agent causing this symptom ; and 5 ) the pentagastrin test with measurements of 5-HT levels in peripheral blood seems to be superior to calcium infusion as a provocative test in documenting the diagnosis of carcinoid disease .
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