The penetration of antibiotics into aggregates of mucoid and non-mucoid Pseudomonas aeruginosa.

@article{Nichols1989ThePO,
  title={The penetration of antibiotics into aggregates of mucoid and non-mucoid Pseudomonas aeruginosa.},
  author={Wright W Nichols and Mark J. Evans and Mary P. E. Slack and H. L. Walmsley},
  journal={Journal of general microbiology},
  year={1989},
  volume={135 5},
  pages={1291-303}
}
Cells of mucoid and non-mucoid Pseudomonas aeruginosa in colonies were at least one-thousandfold less sensitive to the antibiotics tobramycin or cefsulodin than were cells of the same bacteria in dispersed suspension. We did not detect any difference between the mucoid form and the non-mucoid form in the antibiotic sensitivity of colonies, from which we infer that the exopolysaccharide of the mucoid form does not contribute to colony-resistance by forming a barrier to antibiotic diffusion… CONTINUE READING

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