The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study.

@article{Lana2000ThePT,
  title={The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study.},
  author={A Jos{\'e} Lança and Kathryn L Adamson and Kathleen M. Coen and Betty L. C. Chow and William A. Corrigall},
  journal={Neuroscience},
  year={2000},
  volume={96 4},
  pages={735-42}
}
The objective of this study was to determine whether the pedunculopontine tegmental nucleus plays a role in the maintenance of nicotine self-administration, and whether the ascending cholinergic projection from this nucleus to midbrain dopamine neurons in the ventral tegmental area might be involved. Studies were done with rats trained to self-administer nicotine intravenously. Self-administration was examined before and after the pedunculopontine tegmental nucleus was lesioned with the… CONTINUE READING