The pedestrian watchmaker: genetic clocks from engineered oscillators.

  title={The pedestrian watchmaker: genetic clocks from engineered oscillators.},
  author={Natalie Cookson and Lev S. Tsimring and Jeff Hasty},
  journal={FEBS letters},
  volume={583 24},
The crucial role of time-keeping has required organisms to develop sophisticated regulatory networks to ensure the reliable propagation of periodic behavior. These biological clocks have long been a focus of research; however, a clear understanding of how they maintain oscillations in the face of unpredictable environments and the inherent noise of biological systems remains elusive. Here, we review the current understanding of circadian oscillations using Drosophila melanogaster as a typical… CONTINUE READING

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