The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.

@article{McNaught2010ThePO,
  title={The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.},
  author={Kevin St P. McNaught and Ruth Jnobaptiste and Tehone Jackson and Toni-Ann Jengelley},
  journal={Synapse},
  year={2010},
  volume={64 3},
  pages={241-50}
}
The basis of neuronal vulnerability, degeneration, and sparing in PD are unknown, but there is increasing evidence to suggest that the ubiquitin-proteasome system (UPS) plays an important role in the pathogenesis of the disorder. In this study, we employed an immunocytochemical approach to determine if the differential expression of key UPS components in various brain regions and cells might underlie the pattern of neuronal degeneration and survival seen in PD. We showed that the ubiquitin… CONTINUE READING
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