The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia.

@article{Lotfi2006ThePO,
  title={The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia.},
  author={Kourosh Lotfi and Karin Karlsson and Anna Fyrberg and Gunnar Juliusson and Viggo Jonsson and Curt Peterson and Staffan Eriksson and Freidoun Albertioni},
  journal={Biochemical pharmacology},
  year={2006},
  volume={71 6},
  pages={882-90}
}
Deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) catalyze the first step in the intracellular cascade of fludarabine (2-fluoroadenine-beta-D-arabinofuranoside) and cladribine (2-chlorodeoxyadenosine) phosphorylation, which leads to activation of these prodrugs, commonly used for treatment of chronic lymphocytic leukemia (CLL). Thus, resistance to nucleoside analogues may primarily be due to low levels of deoxynucleoside kinase activity. The purpose of this study was to investigate the… CONTINUE READING

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