The pattern of antiganglioside antibody reactivities producing myelinated nerve conduction block in vitro.

@article{Arasaki1998ThePO,
  title={The pattern of antiganglioside antibody reactivities producing myelinated nerve conduction block in vitro.},
  author={Keisuke Arasaki and Susumu Kusunoki and Norio Kudo and Makoto Tamaki},
  journal={Journal of the neurological sciences},
  year={1998},
  volume={161 2},
  pages={163-8}
}
We studied the pattern of human antiganglioside antibody reactivities causing an acute conduction block in rat myelinated nerve fibers, using an in vitro preparation of the sciatic-tibial nerve. With the aid of complements, IgM antibodies reacting with the terminal disaccharide of galactose (beta1-3)N-acetylgalactosamine produced the block. These findings may help us to understand the mechanism in which the conduction block occurs in neuropathies associated with antiganglioside antibodies.