The pathways of mitophagy for quality control and clearance of mitochondria

  title={The pathways of mitophagy for quality control and clearance of mitochondria},
  author={Ghazaleh Ashrafi and Thomas L. Schwarz},
  journal={Cell Death and Differentiation},
Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates removal of mitochondria from developing erythrocytes, and contributes to maternal inheritance of mitochondrial DNA through the elimination of sperm-derived mitochondria. Recent studies have identified specific regulators of mitophagy that ensure selective sequestration of mitochondria as cargo. In yeast, the mitochondrial… 

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