The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase.


The complex organic chemistry involved in the transformation of GTP to tetrahydrobiopterin is catalysed by only three enzymes: GTP cyclohydrolase I, 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. The committing reaction step from GTP to dihydroneopterin triphosphate is catalysed by GTP cyclohydrolase I and requires no cofactor. 6-Pyruvoyl… (More)