The pathway for the production of inositol hexakisphosphate in human cells.

@article{Verbsky2005ThePF,
  title={The pathway for the production of inositol hexakisphosphate in human cells.},
  author={John W. Verbsky and Sunghoe Chang and Monita P. Wilson and Yasuhiro Mochizuki and Philip W. Majerus},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 3},
  pages={
          1911-20
        }
}
The yeast and Drosophila pathways leading to the production of inositol hexakisphosphate (InsP(6)) have been elucidated recently. The in vivo pathway in humans has been assumed to be similar. Here we show that overexpression of Ins(1,3,4)P(3) 5/6-kinase in human cell lines results in an increase of inositol tetrakisphosphate (InsP(4)) isomers, inositol pentakisphosphate (InsP(5)) and InsP(6), whereas its depletion by RNA interference decreases the amounts of these inositol phosphates… CONTINUE READING
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