The pathophysiology of triose phosphate isomerase dysfunction in Alzheimer's disease.

@article{Tajes2013ThePO,
  title={The pathophysiology of triose phosphate isomerase dysfunction in Alzheimer's disease.},
  author={Marta Tajes and Biuse Guivernau and Eva Ramos-Fern{\'a}ndez and M{\'o}nica Bosch-Morat{\'o} and Ernest Palomer and Francesc X Guix and Francisco J Mu{\~n}oz},
  journal={Histology and histopathology},
  year={2013},
  volume={28 1},
  pages={43-51}
}
Alzheimer's disease (AD), the most prevalent neurodegenerative disease worldwide, has two main hallmarks: extracellular deposits of amyloid β-peptide (Aβ) and intracellular neurofibrillary tangles composed by tau protein. Most AD cases are sporadic and are not dependent on known genetic causes; aging is the major risk factor for AD. Therefore, the oxidative stress has been proposed to initiate the uncontrolled increase in Aβ production and also to mediate the Aβ's deleterious effects on brain… CONTINUE READING

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