The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome

  title={The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome},
  author={B. Vasile and F. Rasulo and A. Candiani and N. Latronico},
  journal={Intensive Care Medicine},
  • B. Vasile, F. Rasulo, +1 author N. Latronico
  • Published 2003
  • Medicine
  • Intensive Care Medicine
  • Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically ill children undergoing long-term propofol infusion at high doses. Recently several cases have been reported in adults, too. The main features of the syndrome consist of cardiac failure, rhabdomyolysis, severe metabolic acidosis and renal failure. To date 21 paediatric cases and 14 adult cases have been described. These latter were mostly patients with acute neurological illnesses or acute inflammatory… CONTINUE READING


    Publications referenced by this paper.
    Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.
    • 533
    • Highly Influential
    • PDF
    Impaired fatty acid oxidation in propofol infusion syndrome
    • 328
    Long-term propofol infusion and cardiac failure in adult head-injured patients
    • 392
    • Highly Influential
    Rhabdomyolysis and hypoxia associated with prolonged propofol infusion in children
    • 192
    Polyneuropathy in critically ill patients.
    • 481
    • PDF
    Mechanisms of organ dysfunction in critical illness: report from a Round Table Conference held in Brussels
    • 67
    • Highly Influential
    Paresis acquired in the intensive care unit: a prospective multicenter study.
    • 1,070
    • PDF