The pathophysiology of otosclerosis: Review of current research

@article{Rudi2015ThePO,
  title={The pathophysiology of otosclerosis: Review of current research},
  author={Milan Rudi{\'c} and Ivan Keogh and Richard Wagner and E Wilkinson and Nega Kiros and Evelyne Ferrary and Olivier Sterkers and Alexis Bozorg Grayeli and Kamelija Žarkovi{\'c} and Neven Žarkovi{\'c}},
  journal={Hearing Research},
  year={2015},
  volume={330},
  pages={51-56}
}
Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis… Expand

Paper Mentions

Observational Patient Registry Clinical Trial
Patients with unilateral transmission hypoacusis due to otosclerosis undergoing stapedectomy surgery will be prospectively included. They will be undergoing a free field vocal… Expand
ConditionsOtosclerosis of Middle Ear, Unilateral Hearing Loss
InterventionProcedure
Otosclerosis: From Genetics to Molecular Biology.
TLDR
Current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. Expand
Otosclerosis: An update on diagnosis and treatment
TLDR
The traditional treatment of otosclerosis, stapes surgery, is now being augmented or replaced by innovations in hearing aid technology and cochlear implants. Expand
Update on the imaging diagnosis of otosclerosis
TLDR
The usefulness of imaging techniques for the diagnosis and postsurgical assessment of otosclerosis is reviewed, fundamentally the role of MDCT, to decrease the surgical risk. Expand
Impact of Imaging in Management of Otosclerosis.
The use of imaging in otosclerosis for diagnosis, preoperative assessment, and follow-up has the potential to give the clinician an additional tier of patient evaluation and validation of diagnosis.Expand
Imaging of otosclerosis.
TLDR
This review article focuses on imaging aspects of otosclerosis: current role, advice for imaging technique, characteristic imaging signs, radiological differential diagnoses and findings after stapedoplasty. Expand
The Stapes in Otosclerosis: Osteoarthritis of an Ear Ossicle
TLDR
The present observations suggest that a consequence of otosclerotic ankylosis is osteoarthritis of the stapedal head, and could not be correlated with the severity of hearing loss or duration of clinical disease. Expand
Otosclerosis in an Urban Population
  • Jonathan S Choi, A. Sweeney, +4 authors J. Vrabec
  • Medicine
  • Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2020
TLDR
Otosclerosis in the studied population was most common among Hispanic patients, though it was strongly influenced by country of birth, which is likely due to variance in measles immunization rates among North and Central American countries before 1990. Expand
Otosclerosis: Experience With Stapes Surgery
TLDR
The success rate related to hearing outcomes in patients operated for otosclerosis was excellent and comparable to that found in the current literature. Expand
Diagnostik und operative Therapie der Otosklerose
TLDR
Die Otosklerose ist eine für den HNO-Arzt/Ärztin wichtige, oft in (Differenzial-)Diagnostik und Therapie anspruchsvolle Erkrankung wichtigen wichtiges wichtiger Institutionen. Expand
GPER-1 and sex-hormone levels in patients with otosclerosis.
TLDR
GPER-1 level was lower in the otosclerosis patients compared to healthy volunteers and also lower in females than males in the patient group and these findings indicate that sex-hormones especially estrogen and GP ER-1 might have a potential role in the etiopathogenesis of Otosclerosis. Expand
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