The pathophysiology of chronic pain--increased sensitivity to low threshold A beta-fibre inputs.

@article{Woolf1994ThePO,
  title={The pathophysiology of chronic pain--increased sensitivity to low threshold A beta-fibre inputs.},
  author={Clifford J Woolf and Timothy P Doubell},
  journal={Current opinion in neurobiology},
  year={1994},
  volume={4 4},
  pages={525-34}
}
Chronic pain is characterized by abnormal sensitivity, which is due to the generation of pain in response to the activation of the low-threshold mechanoreceptive A beta fibres that normally generate innocuous sensations. Three different processes in the spinal cord can account for this dramatic alteration in sensory processing in the somatosensory system: increased excitability, decreased inhibition and structural reorganization. All have been shown to occur and each may contribute separately… CONTINUE READING

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