The pathophysiology of acid-base changes in chronically phosphate-depleted rats: bone-kidney interactions.

@article{Emmett1977ThePO,
  title={The pathophysiology of acid-base changes in chronically phosphate-depleted rats: bone-kidney interactions.},
  author={Michael Emmett and Stanley Goldfarb and Zalman S. Agus and Robert G. Narins},
  journal={The Journal of clinical investigation},
  year={1977},
  volume={59 2},
  pages={291-8}
}
Acid-base disturbances may develop secondary to the changes in renal tubular function and bone dynamics which attend phosphate depletion (PD). This work characterizes the acid-base status of rats fed a low phosphate diet. After 18 days, PD rats had marked calciuria (pair-fed controls: 0.3 +/- 0.2; PD 32.2 +/- 2.5 mueq/h; P less than 0.001), severe bicarbonaturia (controls: 0; PD 17.6 +/- 0.2 meq/h; P less than 0.001), and negative net acid excretion (controls: 44.5 +/- 2.9; PD: --6.6 +/- 2.5… CONTINUE READING

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