The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications.

@article{Podar2005ThePR,
  title={The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications.},
  author={Klaus Podar and Kenneth C. Anderson},
  journal={Blood},
  year={2005},
  volume={105 4},
  pages={1383-95}
}
Besides its role as an essential regulator of physiologic and pathologic angiogenesis, vascular endothelial growth factor (VEGF) triggers growth, survival, and migration of leukemia and multiple myeloma cells; plays a pivotal role in hematopoiesis; inhibits maturation of dendritic cells; and increases osteoclastic bone-resorbing activity as well as osteoclast chemotaxis. Dysregulation of VEGF expression and signaling pathways therefore plays an important role in the pathogenesis and clinical… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 138 extracted citations

VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review).

International journal of oncology • 2016
View 13 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 296 references

Human vascular permeability factor. Isolation from U937 cells.

The Journal of biological chemistry • 1989
View 10 Excerpts
Highly Influenced

Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

H Hurwitz, L Fehrenbacher, +12 authors F. Kabbinavar
N Engl J Med • 2004

Similar Papers

Loading similar papers…