The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications.

  title={The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications.},
  author={Klaus Podar and Kenneth C. Anderson},
  volume={105 4},
Besides its role as an essential regulator of physiologic and pathologic angiogenesis, vascular endothelial growth factor (VEGF) triggers growth, survival, and migration of leukemia and multiple myeloma cells; plays a pivotal role in hematopoiesis; inhibits maturation of dendritic cells; and increases osteoclastic bone-resorbing activity as well as osteoclast chemotaxis. Dysregulation of VEGF expression and signaling pathways therefore plays an important role in the pathogenesis and clinical… CONTINUE READING


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