The pathophysiologic profile of congestive heart failure

  title={The pathophysiologic profile of congestive heart failure},
  author={Robert H. Haber and M. D. Thierry LeJemtel and Edmund H. Sonnenblick},
  journal={Cardiovascular Drugs and Therapy},
Congestive heart failure (CHF) evolves either from an excessive workload or in response to loss of myocardium, both of which cause cardiac hypertrophy, increased cardiac pressure, and loss of functional reserve. Nearly 60% of patients in heart failure present with ischemic cardiomyopathy, which in its chronic form exhibits biventricular dilatation, elevated left ventricular mass, and extensive large-vessel atherosclerosis. The hypertrophy is proportional to the loss of myocardium, although… CONTINUE READING