The pathology of adrenocortical neoplasia: a correlated structural and functional approach to the diagnosis of malignant disease.


The structural and functional characteristics of nine functioning adrenocortical tumors (four adenomas and five carcinomas) causing Cushing's syndrome or virilization were studied. All tumors that we considered to show histologic evidence of malignant disease and that subsequently metastasized or recurred also showed in cell culture at least one significant… (More)