The pathological process underlying Alzheimer’s disease in individuals under thirty


Brains of 42 individuals between the ages of 4 and 29 were examined with antibodies (AT8, 4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates associated with Alzheimer’s disease. Thirty-eight of 42 (38/42) cases displayed abnormally phosphorylated tau protein (pretangle material) in nerve cells or in portions of… (More)
DOI: 10.1007/s00401-010-0789-4


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