The pathogenic role of transforming growth factor-β2 in glaucomatous damage to the optic nerve head.


In patients with primary open angle glaucoma (POAG), the optic nerve head (ONH) shows characteristic cupping correlated with visual field defects. The progressive optic neuropathy is characterized by irreversible loss of retinal ganglion cells (RGC). The critical risk factor for axonal damage at the ONH is an elevated intraocular pressure (IOP). The… (More)
DOI: 10.1016/j.exer.2010.07.014