The pathogenesis of virulent and avirulent avian infectious bronchitis virus

@article{Geilhausen1973ThePO,
  title={The pathogenesis of virulent and avirulent avian infectious bronchitis virus},
  author={H. E. Geilhausen and F. B. Ligon and Phil D. Lukert},
  journal={Archiv f{\"u}r die gesamte Virusforschung},
  year={1973},
  volume={40},
  pages={285-290}
}
This study compared the infections of chickens with virulent and avirulent strains of avian infectious bronchitis virus (IBV). Sixty 3-week-old chickens were infected by aerosol with a virulent strain of IBV and 60 with an avirulent strain. Immunofluorescent staining of impression smears and cryostat sections of the trachea revealed that the virulent IBV infected and destroyed the ciliated epithelial cells lining the trachea. The virus then became localized in subepithelial cells and was… CONTINUE READING

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