The pathogenesis of trimethyltin chloride-induced nephrotoxicity.

  title={The pathogenesis of trimethyltin chloride-induced nephrotoxicity.},
  author={Donald G. Robertson and Soo Nam Kim and Robert H. Gray and Felix A de la Iglesia},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={8 2},
In exploratory studies aimed at elucidating CNS effects due to heavy metal toxicity, signs of compromised renal function were seen in rats. The studies reported here describe the sequential steps of the development of nephrotoxicity by trimethyltin chloride (TMT) in rats. Single doses of 12.25 mg/kg TMT administered orally to 150- to 175-g Long-Evans rats elicited overt signs of toxicity including behavioral abnormalities and marked weight loss. Concurrent with the development of these signs… CONTINUE READING