The pathogenesis of spinal cord involvement in dengue virus infection


To investigate the mechanisms of dengue (DEN) virus transmission within the spinal cord, severe combined immunodeficient mice were intracerebrally inoculated with DEN virus type 2. After inoculation, a high virus titer and antigens were detected in the brain and spinal cord. At early stages of the infection, ultrastructural examinations showed that a few… (More)
DOI: 10.1007/s00428-003-0785-3


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