The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.

@article{Hesse2004ThePO,
  title={The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.},
  author={Matthias Hesse and Ciriaco A Piccirillo and Yasmine Belkaid and Jeannette Prufer and Margaret M. Mentink-Kane and Mary Leusink and Allen W. Cheever and Ethan M Shevach and Thomas A. Wynn},
  journal={Journal of immunology},
  year={2004},
  volume={172 5},
  pages={3157-66}
}
IL-10 reduces immunopathology in many persistent infections, yet the contribution of IL-10 from distinct cellular sources remains poorly defined. We generated IL-10/recombination-activating gene (RAG)2-deficient mice and dissected the role of T cell- and non-T cell-derived IL-10 in schistosomiasis by performing adoptive transfers. In this study, we show that IL-10 is generated by both the innate and adaptive immune response following infection, with both sources regulating the development of… CONTINUE READING

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